ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

phenylmethyl 1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylate → 1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylic acid

HRID 1953431
ノート
印刷プレビュー

反応式

HRID 1953431 の反応式
[CH3:1][C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]2([C:23]([O:25]CC3C=CC=CC=3)=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:4])[CH3:3].[H][H]>C(O)C.[C].[Pd]>[CH3:4][C:2]([O:5][C:6]([N:8]1[CH2:13][CH2:12][N:11]([C:14]([NH:16][C:17]2([C:23]([OH:25])=[O:24])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:15])[CH2:10][CH2:9]1)=[O:7])([CH3:1])[CH3:3]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 2

HCID 53984920phenylmethyl 1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 114941311-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylic acid収率 94.8%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702
Ethanol
溶媒

実験手順

Further, 4.3 g (9.65 mmol) of the above phenylmethyl 1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylate was dissolved in 200 ml of ethanol and 400 mg of 10% palladium carbon was suspended thereinto and under air current of hydrogen stirred for 15 hours. The insoluble components were removed from the reaction mixture by filtration. The filtrate was concentrated under reduced pressure, whereby 3.25 g of the captioned 1-[N-[4-(2-methyl-2-propyloxycarbonyl)piperazine-1-carbonyl]amino]cyclohexanecarboxylic acid was obtained in a yield of 45%.

後処理

  1. customThe insoluble components were removed from the reaction mixture by filtration
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-668b042a30a44bb2a925afac02f9697d
出典データセット
uspto-grants-2000_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06117870

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート