Oxalic Acid → 7-Fluoro-5-methyl-1,2,3,4-tetrahydroquinoxaline-2,3-dione
反応式
[NH2:1][C:2]1[C:7]([NH2:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[CH3:10].[C:11](O)(=[O:15])[C:12](O)=[O:13]>Cl.O>[F:9][C:5]1[CH:6]=[C:7]2[C:2]([NH:1][C:11](=[O:15])[C:12](=[O:13])[NH:8]2)=[C:3]([CH3:10])[CH:4]=1参加物
5
実験手順
20 g (0.118 mol) of 2,3-diamino-5-fluorotoluene and 15.8 g (0.176 mol) of oxalic acid are stirred at reflux for 16 hours in 4N hydrochloric acid. The reaction mixture is cooled, diluted with water, filtered off on a suction filter and washed with water. The title compound is obtained as beige crystals of m.p.>300° C.
後処理
- temperatureThe reaction mixture is cooled
- filtrationfiltered off on a suction
- filtrationfilter
- washwashed with water
出典と根拠
- ORDレコード
- ord-1fbbc6035fac439cbe359fc4f3f6efb6
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06117873
反応ノート
読み込み中…