Potassium Carbonate → 2-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

HRID 1953841ノート

反応式

HRID 1953841 の反応式
[CH:1]1([C:4]2C(OC3C=CC(C4C=CC=CC=4C4N=NN(C(OC(=O)C(C)(C)C)C(C)C)N=4)=CC=3)=C(C(O)=O)C3C(=CC=CC=3)N=2)[CH2:3][CH2:2]1.[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:65]=[CH:64][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=5)([C:84]5[CH:89]=[CH:88][CH:87]=[CH:86][CH:85]=5)[C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[N:76]=4)=[CH:62][CH:61]=3)=[C:57]([C:96]([OH:98])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:48][CH2:47]1.[C:99](=[O:102])([O-:101])[O-:100].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[CH:46]1([C:49]2[C:58]([O:59][C:60]3[CH:61]=[CH:62][C:63]([C:66]4[CH:71]=[CH:70][CH:69]=[CH:68][C:67]=4[C:72]4[N:73]=[N:74][N:75]([C:77]([C:90]5[CH:91]=[CH:92][CH:93]=[CH:94][CH:95]=5)([C:78]5[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=5)[C:84]5[CH:85]=[CH:86][CH:87]=[CH:88][CH:89]=5)[N:76]=4)=[CH:64][CH:65]=3)=[C:57]([C:96]([O:98][CH2:4][C:1]3[O:102][C:99](=[O:101])[O:100][C:2]=3[CH3:3])=[O:97])[C:56]3[C:51](=[CH:52][CH:53]=[CH:54][CH:55]=3)[N:50]=2)[CH2:47][CH2:48]1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 100774042-Cyclopropyl-3-[[2'-[2-[1-(2,2-dimethyl-1-oxopropoxy)-2-methylpropyl]-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acidHCID 23298234HCID 23298234、化合物

生成物 1

HCID 571027302-Cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid, (5-methyl-2-oxo-1,3-dioxol-4-yl)methyl ester

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

実験手順

To the title A compound of Example 17, 2-cyclopropyl-3-[[2'-[2-(triphenylmethyl)-2H-tetrazol-5-yl][1,1'-biphenyl]-4-yl]oxy]-4-quinolinecarboxylic acid (1.32 g, 1.91 mmol, 1 eq.), and the title B compound (1.84 g, 9.54 mmol, 5 eq.) in dimethylformamide (3.8 mL, 0.5M), potassium carbonate (0.66 g, 4.77 mmol, 2.5 eq.) was added. The mixture was stirred at room temperature for 21 hours, diluted with ethyl acetate and filtered. The filtrate was washed with ammonium chloride/water and saturated sodium chloride, dried (magnesium sulfate), filtered and concentrated to afford the title compound.

後処理

  1. filtrationfiltered
  2. washThe filtrate was washed with ammonium chloride/water and saturated sodium chloride
  3. dry with materialdried (magnesium sulfate)
  4. filtrationfiltered
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-8425e42db29e42a490c7e9a96d46d5bc
出典データセット
uspto-grants-2000_09
特許番号
US06117885

反応ノート

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