p-Toluenesulfonic acid monohydrate → 2-Isopropyl-1H-indene
反応式
[CH:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH:5]1O)([CH3:3])[CH3:2].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>C1C=CC=CC=1>[CH:1]([C:4]1[CH2:12][C:11]2[C:6]([CH:5]=1)=[CH:7][CH:8]=[CH:9][CH:10]=2)([CH3:3])[CH3:2]参加物
4
実験手順
2-i-Propyl-1-indanol, non-purified, was dissolved in 300 ml of benzene to which was added 5 g of p-toluenesulfonic acid monohydrate and the resulting mixture was refluxed to allow dehydration reaction to occur. After the reaction was over, the reaction mixture was washed with saline, dried over magnesium sulfate, and concentrated in an evaporator. The reaction mixture was purified by column chromatography (silica gel, development solvent: n-hexane) to fractionate the target compound.
後処理
- temperaturethe resulting mixture was refluxed
- customdehydration reaction
- washwas washed with saline
- dry with materialdried over magnesium sulfate
- concentrationconcentrated in an evaporator
- customThe reaction mixture was purified by column chromatography (silica gel, development solvent: n-hexane)
出典と根拠
- ORDレコード
- ord-fbc53dcc22d840bfbac39e4f6bc62e74
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06121182
反応ノート
読み込み中…