Hydrogen Peroxide → Myristamine oxide

HRID 1954490

反応式

HRID 1954490 の反応式
[CH3:1][N:2]([CH3:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16].[OH:18]O.[Al]>>[CH3:1][N+:2]([O-:18])([CH3:17])[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH3:16]

参加物

4

反応物 3

HCID 784Hydrogen PeroxideHCID 8211N,N-Dimethyltetradecylamine2 回HCID 5359268Aluminum

生成物 1

HCID 18739Myristamine oxide

反応条件

温度
41 °C

実験手順

N,N-dimethyl-N-tetradecyl amine (ADMA®14 amine; Albemarle Corporation) (752 g, 3.12 mol) was charged into a 2-liter resin kettle and heated to 41° C. under CO2 blanket before the heating source was removed. Hydrogen peroxide (142 mL, 70%, 3.74 mol) was added over 3.5 hours. The reaction mixture was monitored by 1H-NMR (see Table below). During peroxide addition, the reaction temperature ranged from 41 to 59° C. depending on the peroxide rate of addition. At the end of addition, the slurry was poured into an aluminum pan and was left to stand in a hood over the weekend, after which time 1H-NMR showed complete conversion of the N,N-dimethyl-N-tetradecyl amine to the corresponding oxide. The resulting N,N-dimethyl-N-tetradecyl amine oxide was obtained as snow-white solid block.

後処理

  1. customwas removed
  2. customranged from 41 to 59° C.
  3. additionAt the end of addition
  4. waitwas left

出典と根拠

ORDレコード
ord-893ec16db7c0495c82c716935f42866a
出典データセット
uspto-grants-2000_09
特許番号
US06121490

関連ノート

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