Benzaldehyde → O-benzylbenzaldoxime

HRID 1954748

反応式

HRID 1954748 の反応式
C(O)C.C(=O)([O-])[O-].[K+].[K+].Cl.[CH2:11]([O:18][NH2:19])[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[CH:20](=O)[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>O>[CH2:11]([O:18][N:19]=[CH:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

参加物

6

反応物 4

HCID 240BenzaldehydeHCID 702EthanolHCID 11430Potassium CarbonateHCID 102312Benzyloxyamine hydrochloride

生成物 1

HCID 561973O-benzylbenzaldoxime収率 119%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixture of ethanol (100 mL), potassium carbonate (8.98 g, 65 mmol), and O-benzylhydroxylamine hydrochloride (10.0 g, 62.7 mmol) was added benzaldehvde (6.65 g, 62.7 mmol). The mixture was refluxed for 5 hours, allowed to cool to room temperature, and diluted with water (500 mL). The aqueous solution was extracted with ethyl acetate (500 mL). The organic layer was washed with water, dried over magnesium sulfate, filtered, and concentrated by rotary evaporation to give the title compound as a yellow oil (14.96 g, 119%).

後処理

  1. temperatureThe mixture was refluxed for 5 hours
  2. extractionThe aqueous solution was extracted with ethyl acetate (500 mL)
  3. washThe organic layer was washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated by rotary evaporation

出典と根拠

ORDレコード
ord-83f29f4bfb02481ebc55d3e3b9d72fb5
出典データセット
uspto-grants-2000_09
特許番号
US06124281

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