Ethyl 3-(2-fluorophenyl)prop-2-enoate → Ethyl 3-(2-fluorophenyl)propanoate

HRID 1954873

反応式

HRID 1954873 の反応式
[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH:4]=[CH:5][C:6]([O:8][CH2:9][CH3:10])=[O:7].[H][H]>C(O)C.O.[Pt]=O>[F:1][C:2]1[CH:14]=[CH:13][CH:12]=[CH:11][C:3]=1[CH2:4][CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

5

反応物 2

HCID 590919Ethyl 3-(2-fluorophenyl)prop-2-enoateHCID 178418361HCID 178418361、化合物

生成物 1

HCID 14879014Ethyl 3-(2-fluorophenyl)propanoate収率 99%

試薬・触媒・溶媒 2

HCID 86587499Platinum oxide monohydrate触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 2-fluorocinnamate (29.25 g, 0.176 mol) and platinum oxide hydrate (0.25, EM Scientific) in 95% ethanol (150 mL) was placed on a Parr hydrogenation apparatus and shaken under 2-4 atm at hydrogen pressure. After the appropriate amount of hydrogen was consumed, the catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give 29.39 g (99%) of crude ethyl 3-(2-fluorophenyl)propionate. This material was used without further purification.

後処理

  1. customAfter the appropriate amount of hydrogen was consumed
  2. customthe catalyst was removed by filtration
  3. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-3f6994e5961c472785da87f605f3ac44
出典データセット
uspto-grants-2000_09
特許番号
US06124284

関連ノート

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