(E)-2-(4,6-difluoro-1-indanylidene)acetic acid → (E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

HRID 1954880ノート

反応式

HRID 1954880 の反応式
F[C:2]1[CH:10]=[C:9](F)[CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5]/[C:6]/2=[CH:12]\[C:13]([Cl:15])=[O:14].[F:16]C1C=C(F)C=C2C=1CC/C/2=C\C(O)=O>>[F:16][C:10]1[CH:2]=[C:3]2[C:7](=[CH:8][CH:9]=1)/[C:6](=[CH:12]/[C:13]([Cl:15])=[O:14])/[CH2:5][CH2:4]2

参加物

3

反応物 2

HCID 10976722(E)-2-(4,6-difluoro-1-indanylidene)acetic acidHCID 10977254(E)-2-(4,6-difluoro-1-indanylidene)acetyl Chloride

生成物 1

HCID 23293623(E)-2-(5-fluoro-1-indanylidene)acetyl Chloride

実験手順

This compound was prepared in a similar manner to (E)-2-(4,6-difluoro-1-indanylidene)acetyl chloride in Example 5f by substituting (E)-2-(5-fluoro-1-indanylidene)acetic acid (5.77 g, 0.03 mol) for (E)-2-(4,6-difluoro-1-indanylidene)acetic acid. The resulting solution was concentrated in vacuo, and the residue was used without further purification.

後処理

  1. concentrationThe resulting solution was concentrated in vacuo
  2. customthe residue was used without further purification

出典と根拠

ORDレコード
ord-8fcf4761d31f46b2b202001c3df4c7c2
出典データセット
uspto-grants-2000_09
特許番号
US06124284

反応ノート

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