3-(4-Fluorophenyl)butyryl chloride → 6-Fluoro-3-propyl-1-indanone

反応式

FC1C=CC(C(C)CC(Cl)=O)=CC=1.[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH:21]([CH2:26][CH2:27][CH3:28])[CH2:22][C:23](Cl)=[O:24])=[CH:17][CH:16]=1>>[F:14][C:15]1[CH:20]=[C:19]2[C:18]([CH:21]([CH2:26][CH2:27][CH3:28])[CH2:22][C:23]2=[O:24])=[CH:17][CH:16]=1

参加物

反応物 2

HCID 232936303-(4-Fluorophenyl)butyryl chloride

HCID 232936703-(4-Fluorophenyl) hexanoyl chloride

生成物 1

HCID 232935706-Fluoro-3-propyl-1-indanone収率 98.5%

実験手順

This compound was prepared in an analogous manner to Example 18e with the replace of 3-(4-fluorophenyl)butyryl chloride with 3-(4-fluorophenyl) hexanoyl chloride (49.95 g, 0.218 mol). The dichloromethane extractions were combined, washed with deionized water (250 ml) and concentrated by spin evaporation in vacuo. The residue was coevaporated with dichloromethane (100 ml) to give 41.26 g (98%) of 6-fluoro-3-propyl-1-indanone as a golden yellow syrup:

後処理

customThis compound was prepared in an analogous manner to Example 18e with the
extractionThe dichloromethane extractions
washwashed with deionized water (250 ml)
concentrationconcentrated by spin evaporation in vacuo

出典と根拠

ORDレコード: ord-78969ab1e14b40d998975c53ab665e81
出典データセット: uspto-grants-2000_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06124284

反応ノート

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参加物