3-(3,5-Difluorophenyl)pentanedioic acid → HCID 15896148、化合物
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH:9]([CH2:14][C:15]([OH:17])=O)[CH2:10][C:11]([OH:13])=[O:12])[CH:5]=[C:6]([F:8])[CH:7]=1>CO.ClCCl>[F:8][C:6]1[CH:7]=[C:2]([F:1])[CH:3]=[C:4]2[C:5]=1[C:15](=[O:17])[CH2:14][CH:9]2[CH2:10][C:11]([OH:13])=[O:12]参加物
3
実験手順
This compound was prepared in an analogous manner to that of Example 25d with the replacement of 3-(3-fluorophenyl)glutaric acid with 3-(3,5-difluorophenyl)glutaric acid (9.02 g, 36.9 mmol) and an increase of the heating time from 10 min to 30 min. Chromatography of the collected product on a column of Silica Gel 60 (51×450 mm) with methanol:dichloromethane (4:96) gave a material which was recrystallized from water to give 1.93 g (23%) of 2-(4,6-difluoro-3-oxo-1-indanyl)acetic acid: m.p., 170-172° C.;
後処理
- temperaturean increase of the heating time from 10 min to 30 min
- customwas recrystallized from water
出典と根拠
- ORDレコード
- ord-41e695514f044fef890fd6aa4208ca9a
- 出典データセット
- uspto-grants-2000_09
- 特許番号
- US06124284
反応ノート
読み込み中…