2-Chloroethyl chloroformate → 8-[2-(2-Chloroethoxycarbonylamino)-6-methylbenzylamino]-3-formyl-2-methylimidazo[1,2-a]pyridine

HRID 1954999ノート

反応式

HRID 1954999 の反応式
[NH2:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH:16]=[O:17])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1.Cl[C:24]([O:26][CH2:27][CH2:28][Cl:29])=[O:25]>ClCCl>[Cl:29][CH2:28][CH2:27][O:26][C:24]([NH:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[C:3]=1[CH2:4][NH:5][C:6]1[C:7]2[N:8]([C:12]([CH:16]=[O:17])=[C:13]([CH3:15])[N:14]=2)[CH:9]=[CH:10][CH:11]=1)=[O:25]

参加物

4

反応物 2

HCID 123052-Chloroethyl chloroformateHCID 232941708-(2-Amino-6-methylbenzylamino)-3-formyl-2-methylimidazo[1,2-a]pyridine

生成物 1

HCID 232941788-[2-(2-Chloroethoxycarbonylamino)-6-methylbenzylamino]-3-formyl-2-methylimidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

According to the procedure indicated in Example 1a, 8-(2-amino-6-methylbenzylamino)-3-formyl-2-methylimidazo[1,2-a]pyridine (2.03 g) and 2-chloroethyl chloroformate (1.01 g) in dichloromethane (120 ml) give the title compound as a brown oil, which is used directly for further reaction in Example 3b.

出典と根拠

ORDレコード
ord-49d81300ae384ddfbb9e3ee5f51871a9
出典データセット
uspto-grants-2000_09
特許番号
US06124313

反応ノート

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