(+-)-3-Quinuclidinol → 3-Quinuclidinyl 1-(4-chlorophenyl)cyclobutanecarboxylate Hydrochloride
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:12](Cl)=[O:13])[CH2:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.[N:15]12[CH2:22][CH2:21][CH:18]([CH2:19][CH2:20]1)[CH:17]([OH:23])[CH2:16]2>>[ClH:1].[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([C:12]([O:23][CH:17]3[CH:18]4[CH2:21][CH2:22][N:15]([CH2:20][CH2:19]4)[CH2:16]3)=[O:13])[CH2:11][CH2:10][CH2:9]2)=[CH:6][CH:7]=1参加物
3
実験手順
The title compound was prepared in an analogous manner to that in Example 36 by reacting 1-(4-chlorophenyl)-cyclobutanecarbonyl chloride with 3-quinuclidinol at 80° C. for 25 h. The yield was 0.7 g (43%); mp 205-208° C.; 1H NMR (D2O) δ 1.73-1.85 (m, 2H), 1.86-1.97 (m, 2H), 2.04-2.15 (m, 2H), 2.32 (m, 1H), 2.48-2.63 (m, 2H), 2.87 (m, 2H), 3.12 (m, 1H), 3.22 (d, 1H), 3.27-3.42 (m, 3H), 3.73 (m, 1H), 5.17 (m, 1H), 7.37 (d, 2H), 7.43 (d, 2H). Anal. (C18H22ClNO2.HCl) C, H, N.
後処理
- customat 80° C.
- customfor 25 h