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Hydrochloric Acid → HCID 22001230、化合物

HRID 1955383
ノート
印刷プレビュー

反応式

HRID 1955383 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:33]=[C:32]([OH:34])[CH:31]=[CH:30][C:11]=3[C:12]=2[C:13](=[O:29])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][N:23]3[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]3)=[CH:16][CH:15]=2)=[CH:4][CH:3]=1.[ClH:35].O>CO>[ClH:35].[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:33]=[C:32]([OH:34])[CH:31]=[CH:30][C:11]=3[C:12]=2[C:13](=[O:29])[C:14]2[CH:15]=[CH:16][C:17]([O:20][CH2:21][CH2:22][N:23]3[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]3)=[CH:18][CH:19]=2)=[CH:4][CH:3]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 99557562-(4-Hydroxyphenyl)-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-hydroxybenzofuran

生成物 1

HCID 22001230HCID 22001230、化合物収率 84%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒2 回

反応条件

温度
0 °C

実験手順

The title compound was prepared by dissolving the compound of Example 19, 2-(4-hydroxyphenyl)-3-[4-[2-(piperidin-1-yl)ethoxy]benzoyl]-6-hydroxybenzofuran, (3.1 g, 6.8 mmol) in 15 ml of methanol and treating with an excess of 3% hydrochloric acid in methanol. The volume was then reduced by boiling to 15 ml. Warm water (20 ml) was then added and the reaction mixture was further warmed to clarify. The reaction mixture was then filtered, followed by gradual cooling to 0° C., at which temperature the mixture was maintained for about one hour. The crystals, which had precipitated, were collected by filtration and washed with cold water. The pale yellow crystals were dried overnight, resulting in 2.82 g (84%) of the desired title product. mp 213-215° C.

後処理

  1. customThe title compound was prepared
  2. temperaturethe reaction mixture was further warmed to clarify
  3. filtrationThe reaction mixture was then filtered
  4. temperaturewas maintained for about one hour
  5. customThe crystals, which had precipitated
  6. filtrationwere collected by filtration
  7. washwashed with cold water
  8. customThe pale yellow crystals were dried overnight

出典と根拠

ORDレコード
ord-3faede9c633f4ae68e70d231429644ca
出典データセット
uspto-grants-2000_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US06124311

反応ノート

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