Hydrochloric Acid → 6-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid

HRID 19554

反応式

HRID 19554 の反応式
C[O:2][C:3]([C:5]1[C:6](=[O:21])[C:7]2[C:12]([C:13]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[CH:11][CH:10]=[C:9]([OH:20])[CH:8]=2)=[O:4].CSC.B(Br)(Br)Br.C(=O)(O)[O-].[Na+].Cl>ClC(Cl)C>[OH:20][C:9]1[CH:8]=[C:7]2[C:12]([C:13]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[C:5]([C:3]([OH:4])=[O:2])[C:6]2=[O:21])=[CH:11][CH:10]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 516892Sodium BicarbonateHCID 10946916Boron tribromide methyl sulfideHCID 687002636-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester

生成物 1

HCID 686989826-hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid収率 48.6%

試薬・触媒・溶媒 1

HCID 63651,1-Dichloroethane溶媒

反応条件

温度
90 °C

実験手順

6-Hydroxy-1-oxo-3-phenyl-1H-indene-2-carboxylic acid methyl ester (2.6 g, 9.28 mmol) obtained in Step 1 was dissolved in dichloroethane, and boron tribromide methyl sulfide (6.0 mL, 27.84 mmol) was added thereto. The mixture was refluxed for 2 hrs at 90° C., cooled in an ice bath, neutralized using sodium bicarbonate, and adjusted to pH 2 using 6N hydrochloric acid. The resulting mixture washed successively with dichloromethane and water. The organic layer was separated, dried over anhydrous MgSO4, concentrated under a reduced pressure and recrystallized to obtain 1.2 g of the titled compound (yield: 48.6%).

後処理

  1. temperaturecooled in an ice bath
  2. washThe resulting mixture washed successively with dichloromethane and water
  3. customThe organic layer was separated
  4. dry with materialdried over anhydrous MgSO4
  5. concentrationconcentrated under a reduced pressure
  6. customrecrystallized

出典と根拠

ORDレコード
ord-df3eb7c1c5c742609cdcc4e6d4b8dcbe
出典データセット
uspto-grants-2010_06
特許番号
US07745439B2

関連ノート

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