Bromine → N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamide

HRID 1955786ノート

反応式

HRID 1955786 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:10])[CH3:9])=[CH:4][C:3]=1[NH:11][S:12]([CH3:15])(=[O:14])=[O:13].[Br:16]Br>O1CCOCC1>[Br:16][CH2:9][C:8]([C:5]1[CH:6]=[CH:7][C:2]([OH:1])=[C:3]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:4]=1)=[O:10]

参加物

4

反応物 2

HCID 24408BromineHCID 19073226N-(5-acetyl-2-hydroxyphenyl)methanesulfonamide

生成物 1

HCID 19073169N-(5-(2-bromoacetyl)-2-hydroxyphenyl)methanesulfonamide収率 90.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

To a stirred 60° C. dioxane (35 mL) solution of 1-[4-hydroxy-3-[(methylsulfonyl)amino]phenyl]ethanone (2.06 g, 8.7 mmol) was rapidly added Br2 (1.48 g, 9.2 mmol). After one hour, the solution was cooled, concentrated and diluted with H2O. After filtration, the product was washed thoroughly with H2O, then with i-PrOH (9 mL), and air-dried to obtain the title compound (2.43 g, 84%).

後処理

  1. customTo a stirred 60° C.
  2. temperaturethe solution was cooled
  3. concentrationconcentrated
  4. additiondiluted with H2O
  5. filtrationAfter filtration
  6. washthe product was washed thoroughly with H2O
  7. dry with materialwith i-PrOH (9 mL), and air-dried

出典と根拠

ORDレコード
ord-b3ea20147bd9433e8acbac29c47f0f5f
出典データセット
uspto-grants-1998_07
特許番号
US05776983

反応ノート

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