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3'-O-Amino-(t-butyldimethylsilyl)thymidine → 3'-o-Aminothymidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3'-O-Amino-(t-butyldimethylsilyl)thymidine | HCID 69101893 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 3'-o-Aminothymidine | HCID 190488 | 72% |
反応手順
3'-O-Amino-(t-butyldimethylsilyl)thymidine was deblocked with (Bu)4 NF/THF in standard way to furnish compound 4 (72%). Crystallized from ether/hexanes/ethanol as fine needles, mp 81° C. 1H NMR (Me2SO--d6) δ1.78 (s, 3, CH3), 2.17 and 2.45 (2 m, 2, 2'CH2), 3.70 (m, 2, 5'CH2), 3.88 (m, 1, 4'H), 4.16 (m, 1, 3'H), 4.8 (br s, 1, 5'OH), 6.05 (dd, 1, 1'H), 6.2 (br s, 2 NH2), 7.48 (s, 1, C6H), and 11.24 (br s, 1, NH). Anal. Calcd. for C10 H15N3O5 : C, 46.69; H, 5.87; N, 16.33; found: C, 46.55; H, 5.91; N, 16.21.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05777092 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-22d2ed9e65cf404e9201abc44b183f8b |
| 出典メモ | uspto-grants-1998_07 |