Diethyl (ethoxymethylene)malonate → Diethyl (6-ethoxy-2-pyridylamino)methylenemalonate
反応式
[CH2:1]([O:3][C:4]1[N:9]=[C:8]([NH2:10])[CH:7]=[CH:6][CH:5]=1)[CH3:2].C(O[CH:14]=[C:15]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[C:16]([O:18][CH2:19][CH3:20])=[O:17])C>>[CH2:1]([O:3][C:4]1[N:9]=[C:8]([NH:10][CH:14]=[C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH:7]=[CH:6][CH:5]=1)[CH3:2]参加物
3
反応条件
- 温度
- 95 °C
実験手順
A mixture of 6-ethoxypyridin-2-amine (8.0 g) and diethyl ethoxymethylenemalonate (12.5 g) was heated at 95° C. under vacuum for 3 hours and then heated at 95° C. at atmospheric pressure for 18 hours. The mixture was cooled to ambient temperature, diluted with petroleum ether b.p. 40°-60° C. and filtered to give diethyl (6-ethoxy-2-pyridylamino)methylenemalonate, m.p. 58°-60° C.
後処理
- temperatureheated at 95° C. at atmospheric pressure for 18 hours
- temperatureThe mixture was cooled to ambient temperature
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-eb828d94feaf40fd850dd8bc8ce6fcbd
- 出典データセット
- uspto-grants-1998_07
- 特許番号
- US05780482
反応ノート
読み込み中…