Aluminium lithium hydride → 3-Benzyloxymethylcyclohexylamine
反応式
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][C:12](=[N:16]O)[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>C(OCC)C>[CH2:1]([O:8][CH2:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH:12]([NH2:16])[CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
To a solution of the compound (12) (0.75 g; 3.2 mmol) in diethyl ether (30 ml), lithium aluminum hydride (0.75 g; 20 mmol) is added, and the resultant mixture is refluxed for 3 hours. After cooling, wet ether is dropwise added to the reaction mixture, and the organic layer is collected by decantation and dried, followed by concentration under reduced pressure to give 3-benzyloxymethylcyclohexylamine (13) (0.61 g).
後処理
- temperatureAfter cooling
- customthe organic layer is collected by decantation
- customdried
- concentrationfollowed by concentration under reduced pressure
出典と根拠
- ORDレコード
- ord-cd066af7b96146eab9b46afe8e8f079d
- 出典データセット
- uspto-grants-1998_07
- 特許番号
- US05780632
反応ノート
読み込み中…