Ethylenediamine → Ethyl 2-fluorocyclopropanecarboxylate

HRID 1956830

反応式

HRID 1956830 の反応式
Br[C:2]1([F:10])[CH2:4][CH:3]1[C:5]([O:7][CH2:8][CH3:9])=[O:6].NCCN>[C].[Pd].C(O)C>[F:10][CH:2]1[CH2:4][CH:3]1[C:5]([O:7][CH2:8][CH3:9])=[O:6]

参加物

5

反応物 2

HCID 3301EthylenediamineHCID 22371314Ethyl 2-bromo-2-fluoro-1-cyclopropanecarboxylate

生成物 1

HCID 10313150Ethyl 2-fluorocyclopropanecarboxylate収率 81%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

An internal glass tube was introduced into an autoclave and 211 mg of ethyl 2-bromo-2-fluoro-1-cyclopropanecarboxylate [obtained in accordance with the method of Bulletin of Faculty of Education, Wakayama University, 33, 33 (1984); cis:trans=0.8:1], 40 mg of 5% palladium-carbon (moisture content: 55% wet) and 8 ml of ethanol were fed thereinto. Then 90 mg of 1,2-diaminoethane was further added and the mixture was stirred at room temperature under an elevated hydrogen gas atmosphere (50 kgf/cm2) for 48 hours. After the completion of the reaction, the catalyst was filtered off. Then the reaction mixture containing the title compound was analyzed by gas chromatography. As a result, it was found out that the reaction conversion rate was 95%, the yield was 81% and the cis:trans ratio was 0.8:1.

後処理

  1. customobtained in accordance with the method of Bulletin of Faculty of Education, Wakayama University, 33, 33 (1984)
  2. customAfter the completion of the reaction
  3. filtrationthe catalyst was filtered off
  4. additionThen the reaction mixture containing the title compound

出典と根拠

ORDレコード
ord-a23483b85c3847ae89ac28c8fbfe16b5
出典データセット
uspto-grants-1998_07
特許番号
US05780669

関連ノート

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