4-Chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine → 2-(Methylsulfonyl)thieno[2,3-d]pyrimidine
反応式
Cl[C:2]1[C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=[C:6]([S:8]([CH3:11])(=[O:10])=[O:9])[N:7]=1>C(O)C>[CH3:11][S:8]([C:6]1[N:7]=[CH:2][C:3]2[CH:14]=[CH:13][S:12][C:4]=2[N:5]=1)(=[O:9])=[O:10]参加物
3
実験手順
To 500 mL round-bottom flask was added 4-chloro-2-(methylsulfonyl)thieno[2,3-d]pyrimidine (15 g, 60 mmol), ethyl alcohol (300 mL), nitrogen gas was bubbled for 5 minutes. To this solution was added 10% palladium on activated charcoal (15 g). To the resulting mixture was bubbled hydrogen gas over night. The reaction mixture was filtered through Celite. The filtrate was concentrated to give the title compound (11.0 g). MS (ES+): 215 (M+H)+.
後処理
- customwas bubbled for 5 minutes
- additionTo this solution was added 10% palladium on activated charcoal (15 g)
- customTo the resulting mixture was bubbled hydrogen gas over night
- filtrationThe reaction mixture was filtered through Celite
- concentrationThe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-398d0eeeef004e768af1392b96843f9b
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745449B2
反応ノート
読み込み中…