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Methyl tryptophanate hydrochloride → N-(3,5-dimethylbenzoyl)-N-methyl-O-methyl-(D)-tyrosyl-(L)-tryptophan
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl tryptophanate hydrochloride | HCID 2734891 | — |
| 反応物 | N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosyl-(L)-tryptophan | HCID 67675232 | — |
| 生成物 | N-(3,5-dimethylbenzoyl)-N-methyl-O-methyl-(D)-tyrosyl-(L)-tryptophan | HCID 67674645 | — |
反応手順
Coupling of N-(3,5-dimethylbenzoyl)-N-methyl-O-methyl-(D)-tyrosine (prepared by O-methylation of N-(3,5-dimethylbenzoyl)-N-methyl-(D)-tyrosine (example 64)) with (L)-tryptophan methyl ester hydrochloride according to example 1 followed by hydrolysis of the methyl ester moiety according to example 12 gives N-(3,5-dimethylbenzoyl)-N-methyl-O-methyl-(D)-tyrosyl-(L)-tryptophan; FAB-MS m/e 528 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05780498 |
| 出典データセット | uspto-grants-1998_07 |
| ORD ID | ord-72ef96e7591149e7b1f9a21c90168308 |
| 出典メモ | uspto-grants-1998_07 |