Acetamidine monohydrochloride → HCID 178499609、化合物

HRID 1957172ノート

反応式

HRID 1957172 の反応式
[CH:1]([C:11]([O:13]C)=O)([C:7](OC)=[O:8])[CH2:2][C:3]([O:5][CH3:6])=[O:4].Cl.[C:16]([NH2:19])(=[NH:18])[CH3:17].C[O-].[Na+]>CO>[OH:13][C:11]1[C:1]([CH2:2][C:3]([O:5][CH3:6])=[O:4])=[C:7]([OH:8])[N:19]=[C:16]([CH3:17])[N:18]=1

参加物

5

反応物 3

HCID 67170Acetamidine monohydrochlorideHCID 2911921,1,2-Trimethyl ethane-1,1,2-tricarboxylateHCID 10942334Sodium Methoxide

生成物 1

HCID 178499609HCID 178499609、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Trimethyl ethane-1,1,2-tricarboxylate (204 g, 1 mol) and acetamidine hydrochloride (95 g, 1 mol) are added to a solution of sodium methylate (108 g, 2 mol) in methanol (600 ml) with stirring. The mixture is stirred for 16 hours at room temperature. Acidification with concentrated hydrochloric acid, filtration, washing with cold water and drying gives the methyl 4,6-dihydroxy-2-methyl-pyrimidin-5-yl-acetate (or tautomeric forms thereof) as a colorless solid (210 g), m.p.>200° C.

後処理

  1. stirringThe mixture is stirred for 16 hours at room temperature
  2. filtrationAcidification with concentrated hydrochloric acid, filtration
  3. washwashing with cold water
  4. customdrying

出典と根拠

ORDレコード
ord-c566cc7fc5204cd3ab2a6b8bc5de8414
出典データセット
uspto-grants-1998_07
特許番号
US05783580

反応ノート

読み込み中…