Sulfuric Acid → 2-Chloro-5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]benzaldehyde

HRID 1957246ノート

反応式

HRID 1957246 の反応式
[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH:19](Br)Br)[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.S(=O)(=O)(O)[OH:23]>>[Cl:1][C:2]1[C:3]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[C:14]([CH:19]=[O:23])[CH:13]=2)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

参加物

3

反応物 2

HCID 1118Sulfuric AcidHCID 19068769HCID 19068769、化合物

生成物 1

HCID 186929322-Chloro-5-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]benzaldehyde

実験手順

6.99 g (15.1 mmol) of 3-chloro-2-(4-chloro-3-dibromomethylphenyl)-5-trifluoromethylpyridine in 100 ml of 96% strength sulfuric acid were stirred at 100° C. for one hour during which a vigorous stream of nitrogen was passed through the reaction mixture. The mixture was cooled and then poured into ice-water. The solid product was separated off, washed with water and dried under reduced pressure. Yield: 4.2 g (87%) of colorless crystals of melting point 94° C.

後処理

  1. temperatureThe mixture was cooled
  2. customThe solid product was separated off
  3. washwashed with water
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-99a28b86363e4437900b8a2de1b05992
出典データセット
uspto-grants-1998_07
特許番号
US05783522

反応ノート

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