Ethanol → 1-(1,2-Benzisoxazol-3-yl)ethanol
反応式
C([O:4][CH:5]([C:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[O:9][N:8]=1)[CH3:6])(=O)C.[OH-].[K+].C(O)C>O>[O:9]1[C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:7]([CH:5]([OH:4])[CH3:6])=[N:8]1参加物
5
実験手順
A mixture of 2.6 g of 3-(1-acetoxyethyl)-1,2-benzisoxazole, 0.9 g of potassium hydroxide, 40 ml of ethanol and 3 ml of water is stirred for 1 h at room temperature. The reaction mixture is then concentrated under vacuum and diluted with water. This aqueous phase is extracted three times with diethyl ether, the combined ethereal extracts are then washed with a saturated solution of sodium chloride and dried over sodium sulfate, giving 1-(1,2-benzisoxazol-3-yl)ethanol as an oil having a refractive index nD20 of 1.5555.
後処理
- concentrationThe reaction mixture is then concentrated under vacuum
- additiondiluted with water
- extractionThis aqueous phase is extracted three times with diethyl ether
- washthe combined ethereal extracts are then washed with a saturated solution of sodium chloride
- dry with materialdried over sodium sulfate
出典と根拠
- ORDレコード
- ord-e46a4847bc584047af11a68dbe52fe30
- 出典データセット
- uspto-grants-1998_07
- 特許番号
- US05786374
反応ノート
読み込み中…