Sodium methanesulfinate → 1-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene

HRID 1957956ノート

反応式

HRID 1957956 の反応式
Cl[CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1.[Na+].[CH3:17][S:18]([O-:20])=[O:19]>CO>[CH3:17][S:18]([CH2:2][C:3]1[CH:8]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:6]=[C:5]([N+:13]([O-:15])=[O:14])[CH:4]=1)(=[O:20])=[O:19]

参加物

4

反応物 2

HCID 2733271Sodium methanesulfinateHCID 684250951-(Chloromethyl)-3-nitro-5-(trifluoromethyl)benzene

生成物 1

HCID 684233041-Methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene収率 92.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1-chloromethyl-3-nitro-5-trifluoromethyl-benzene (520 mg; 2.170 mmol) and methanesulfinic acid sodium salt (664 mg; 6.511 mmol) in Methanol (10 ml) of was refluxed overnight. The reaction was then cooled to room temperature and the product precipitated was filtered and diluted with dichloromethane. The solid was removed and the organic phase was concentrated in vacuo 520 mg (2 mmol; 85% yield) of 1-methylsulfonylmethyl-3-nitro-5-trifluoromethyl-benzene were obtained.

後処理

  1. customthe product precipitated
  2. filtrationwas filtered
  3. additiondiluted with dichloromethane
  4. customThe solid was removed

出典と根拠

ORDレコード
ord-c521c703272c4832b7d389f592e4fd42
出典データセット
uspto-grants-2013_04
特許番号
US08410100B2

反応ノート

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