Nicotinic Acid → (S)-N-(5-(4-chlorophenyl)-6-(1,1,1-trifluoropropan-2-yloxy)pyridin-3-yl)nicotinamide
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([NH2:21])[CH:11]=[N:12][C:13]=2[O:14][C@@H:15]([CH3:20])[C:16]([F:19])([F:18])[F:17])=[CH:4][CH:3]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28](O)=[O:29])[CH:23]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[C:10]([NH:21][C:28](=[O:29])[C:24]3[CH:25]=[CH:26][CH:27]=[N:22][CH:23]=3)[CH:11]=[N:12][C:13]=2[O:14][C@@H:15]([CH3:20])[C:16]([F:17])([F:18])[F:19])=[CH:6][CH:7]=1参加物
3
実験手順
The title compound was synthesized in analogy to Example 42g, using 5-(4-chloro-phenyl)-6-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-pyridin-3-ylamine (example 420 and 3-pyridine carboxylic acid (CAN 59-67-6) as starting materials; MS (EI) 422.0 (M+H)+.
出典と根拠
- ORDレコード
- ord-240ca0a4d47e45348835d5ebf942a331
- 出典データセット
- uspto-grants-2013_04