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(Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate → (+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (Oxiran-2-yl)methyl 3-nitrobenzene-1-sulfonate | HCID 286836 | — |
| 反応物 | 1-(Cyclohexylmethyl)piperazine | HCID 2735885 | — |
| 生成物 | (+/-)-1-(Cyclohexylmethyl)-4-(oxiran-2-ylmethyl)piperazine | HCID 86661984 | 92% |
反応手順
The same method as employed in the preparation of Intermediate 1 but starting from 1-cyclohexylmethyl piperazine and (±)-3-nitro-benzenesulfonic acid oxiranylmethyl ester gives after flash chromatography the title compound as a yellow oil in a 92% yield.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08410110B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-2536eeedebbf49a0b6412589d7783b57 |
| 出典メモ | uspto-grants-2013_04 |