Acetic Anhydride → N-[(1R,2S)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]acetamide
反応式
[NH2:1][C@@H:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][C@@H:3]1[OH:11].[C:12](OC(=O)C)(=[O:14])[CH3:13]>C(Cl)Cl>[OH:11][C@H:3]1[CH2:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C@H:2]1[NH:1][C:12](=[O:14])[CH3:13]参加物
4
実験手順
(1R,2S)-1-amino-2-indanol (2.0 g, 13.4 mmol) is suspended in 100 mL DCM and at RT it is combined with acetic anhydride (1.27 mL, 13.4 mmol). The reaction mixture is stirred for 1 h at RT, once the reaction is complete the solvent is eliminated using the rotary evaporator and the crude product B-1b (HPLC-MS: tRet.=0.81 min; MS (M+H)+=192) is used in the subsequent reactions without further purification.
後処理
- customthe rotary evaporator
- customthe crude product B-1b (HPLC-MS: tRet.=0.81 min; MS (M+H)+=192) is used in the subsequent reactions without further purification
出典と根拠
- ORDレコード
- ord-114fe4fbef9c4da6ab257f5a2b9eca38
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08410126B2
反応ノート
読み込み中…