Sodium Methoxide → (4-{3-[2,6-bis(trifluoromethyl)pyridin-4-yl]-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl}-2-bromophenyl)methanol

HRID 1958631ノート

反応式

HRID 1958631 の反応式
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH2:13][C:14]([C:21]3[CH:26]=[C:25]([C:27]([F:30])([F:29])[F:28])[N:24]=[C:23]([C:31]([F:34])([F:33])[F:32])[CH:22]=3)([C:17]([F:20])([F:19])[F:18])[CH2:15][N:16]=2)=[CH:8][C:7]=1[Br:35])(=O)C.C[O-].[Na+]>CO.C(OC)(C)(C)C>[F:34][C:31]([F:32])([F:33])[C:23]1[CH:22]=[C:21]([C:14]2([C:17]([F:18])([F:19])[F:20])[CH2:13][C:12]([C:9]3[CH:10]=[CH:11][C:6]([CH2:5][OH:4])=[C:7]([Br:35])[CH:8]=3)=[N:16][CH2:15]2)[CH:26]=[C:25]([C:27]([F:28])([F:29])[F:30])[N:24]=1

参加物

5

反応物 2

HCID 10942334Sodium MethoxideHCID 866646224-{3-[2,6-bis(trifluoromethyl)pyridin-4-yl]-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl}-2-bromobenzyl acetate

生成物 1

HCID 86664623(4-{3-[2,6-bis(trifluoromethyl)pyridin-4-yl]-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl}-2-bromophenyl)methanol

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 15413tert-Butyl methyl ether溶媒

実験手順

4-{3-[2,6-bis(trifluoromethyl)pyridin-4-yl]-3-(trifluoromethyl)-3,4-dihydro-2H-pyrrol-5-yl}-2-bromobenzyl acetate (0.5 g) and Sodium methoxide (0.005 g) in MeOH (10 ml) were stirred at room temperature for 30 minutes. The mixture was diluted with t-BuOMe, and washed with brine, and the organic layer was dried over MgSO4. After the solvent was evaporated under reduced pressure, the targeted product was obtained (0.4 g).

後処理

  1. washwashed with brine
  2. dry with materialthe organic layer was dried over MgSO4
  3. customAfter the solvent was evaporated under reduced pressure
  4. customthe targeted product was obtained (0.4 g)

出典と根拠

ORDレコード
ord-6ae48798a2a7471e8fa238b4de8a74cf
出典データセット
uspto-grants-2013_04
特許番号
US08410141B2

反応ノート

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