Ammonia → Benzyl 4-sulfamoylpiperidine-1-carboxylate

HRID 1959093ノート

反応式

HRID 1959093 の反応式
Cl[S:2]([CH:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3].[NH3:21]>>[NH2:21][S:2]([CH:5]1[CH2:10][CH2:9][N:8]([C:11]([O:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[O:12])[CH2:7][CH2:6]1)(=[O:4])=[O:3]

参加物

3

反応物 2

HCID 222AmmoniaHCID 21931260Benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate

生成物 1

HCID 59353042Benzyl 4-sulfamoylpiperidine-1-carboxylate

実験手順

To a solution of 0.88 NH3 (50 ml) was added benzyl 4-(chlorosulfonyl)piperidine-1-carboxylate (4 g) and the reaction stirred for 72 h at RT. The reaction was then extracted with DCM (3×150 ml). Organics were recovered, dried (MgSO4) and reduced in vacuo to give the subtitle compound as a clear oil. Yield 3.3 g

後処理

  1. extractionThe reaction was then extracted with DCM (3×150 ml)
  2. customOrganics were recovered
  3. dry with materialdried (MgSO4)

出典と根拠

ORDレコード
ord-b756c462f4ba4dab95ced1e5b56425a8
出典データセット
uspto-grants-2013_04
特許番号
US08410123B2

反応ノート

読み込み中…