Imidazole → 8-Hydroxy-4-(1H-imidazol-yl)-2-methylquinoline
反応式
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[NH:14]1[CH:18]=[CH:17][N:16]=[CH:15]1>O1CCOCC1>[N:14]1([C:2]2[C:11]3[C:6](=[C:7]([OH:12])[CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([CH3:13])[CH:3]=2)[CH:18]=[CH:17][N:16]=[CH:15]1参加物
4
実験手順
A mixture of 4-chloro-2-methyl-quinolin-8-ol (2.0 g, 10 mmol) and imidazole (3.53 g, 51.8 mmol) in dioxane (20 mL) was heated to reflux for 28 h. The solvent was removed in vacuo and the residue was purified by flash chromatography on silica gel (elution with DCM/methanol 10:1) to give the title compound. MS (m/z): 226.3 [M+H+].
後処理
- temperaturewas heated
- temperatureto reflux for 28 h
- customThe solvent was removed in vacuo
- customthe residue was purified by flash chromatography on silica gel (elution with DCM/methanol 10:1)
出典と根拠
- ORDレコード
- ord-653e6d7c75f54932bd69a4ffcd6a882c
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08410134B2
反応ノート
読み込み中…