N-Methylisopropylamine → 2-Bromo-N-isopropyl-N-methyl-acetamide

HRID 1959572ノート

反応式

HRID 1959572 の反応式
[CH:1]([NH:4][CH3:5])([CH3:3])[CH3:2].[N+](C1C=C([N+]([O-])=O)C=CC=1O[C:19](=[O:22])[CH2:20][Br:21])([O-])=O>C(Cl)Cl>[Br:21][CH2:20][C:19]([N:4]([CH:1]([CH3:3])[CH3:2])[CH3:5])=[O:22]

参加物

4

反応物 2

HCID 78485N-MethylisopropylamineHCID 11278141Bromo-acetic acid 2,4-dinitro-phenyl ester

生成物 1

HCID 205943482-Bromo-N-isopropyl-N-methyl-acetamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Isopropyl-methyl-amine (154 μL, 1.48 mmol) was added to a stirred solution of bromo-acetic acid 2,4-dinitro-phenyl ester (450 mg, 1.48 mmol) in DCM (4 mL). After stirring for 3 h at room temperature the organic layer was extracted twice with 0.1 M NaOH solution (30 mL). The organic layer was dried over Na2SO4, filtered, and concentrated in vacuo. The resulting title compound was used for the next reaction without purification. MS (m/z): 194.0 [M+H+].

後処理

  1. extractionwas extracted twice with 0.1 M NaOH solution (30 mL)
  2. dry with materialThe organic layer was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated in vacuo
  5. customThe resulting title compound was used for the next reaction without purification

出典と根拠

ORDレコード
ord-42b1851bbde7487390a5cbecead28780
出典データセット
uspto-grants-2013_04
特許番号
US08410134B2

反応ノート

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