Dichloromethane → N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide

HRID 1959576ノート

反応式

HRID 1959576 の反応式
[Cl:1][C:2]1[C:3]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:4]([CH2:8][NH2:9])[CH:5]=[N:6][CH:7]=1.C(Cl)Cl.[C:21](Cl)(=[O:25])[CH:22]([CH3:24])[CH3:23]>>[Cl:1][C:2]1[C:3]([CH2:10][O:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][O:13]2)=[C:4]([CH2:8][NH:9][C:21](=[O:25])[CH:22]([CH3:24])[CH3:23])[CH:5]=[N:6][CH:7]=1

参加物

4

反応物 3

HCID 6344DichloromethaneHCID 62325Isobutyryl chlorideHCID 67077948C-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-methylamine

生成物 1

HCID 67077454N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide

実験手順

To a solution of C-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-yl]-methylamine (0.37 g, 1.4 mmol) in DCM (20 mL) DIPEA (0.41 mL, 2.2 mmol) and isobutyryl chloride (0.18 mL, 1.6 mmol) were added. Stirring was continued overnight at RT. The solvent was evaporated and the residue was used in the following step without further purification. MS (m/z): 326.9 [M+H+].

後処理

  1. customThe solvent was evaporated
  2. customthe residue was used in the following step without further purification

出典と根拠

ORDレコード
ord-4b5d426e0bc24c26b47b8a0118b8b7b0
出典データセット
uspto-grants-2013_04
特許番号
US08410134B2

反応ノート

読み込み中…