N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide → N-(5-Chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-isobutyramide

HRID 1959577ノート

反応式

HRID 1959577 の反応式
ClC1C(CO)=C(C(=O)COC)C=NC=1.[Cl:15][C:16]1[C:17]([CH2:29][O:30]C2CCCCO2)=[C:18]([CH2:22][NH:23][C:24](=[O:28])[CH:25]([CH3:27])[CH3:26])[CH:19]=[N:20][CH:21]=1>>[Cl:15][C:16]1[C:17]([CH2:29][OH:30])=[C:18]([CH2:22][NH:23][C:24](=[O:28])[CH:25]([CH3:26])[CH3:27])[CH:19]=[N:20][CH:21]=1

参加物

3

反応物 2

HCID 67077454N-[5-Chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramideHCID 670774851-(5-Chloro-4-hydroxymethyl-pyridin-3-yl)-2-methoxy-ethanone

生成物 1

HCID 67077216N-(5-Chloro-4-hydroxymethyl-pyridin-3-ylmethyl)-isobutyramide

実験手順

Deprotection of the tetrahydropyranyl group in N-[5-chloro-4-(tetrahydro-pyran-2-yloxymethyl)-pyridin-3-ylmethyl]-isobutyramide according to the synthesis of 1-(5-chloro-4-hydroxymethyl-pyridin-3-yl)-2-methoxy-ethanone yielded the title compound. MS (m/z): 243.0 [M+H+].

出典と根拠

ORDレコード
ord-0f48b58622414ce1aa90dbef6993b809
出典データセット
uspto-grants-2013_04
特許番号
US08410134B2

反応ノート

読み込み中…