Sulfuryl chloride → 4-(7-Chloro-5-fluoro-6-methoxybenzothiazol-2-YL)-5-methyl-1H-pyrazol-3-ylamine
反応式
[F:1][C:2]1[C:3]([O:18][CH3:19])=[CH:4][C:5]2[S:9][C:8]([C:10]3[C:14]([CH3:15])=[N:13][NH:12][C:11]=3[NH2:16])=[N:7][C:6]=2[CH:17]=1.S(Cl)([Cl:23])(=O)=O>>[Cl:23][C:4]1[C:5]2[S:9][C:8]([C:10]3[C:11]([NH2:16])=[N:12][NH:13][C:14]=3[CH3:15])=[N:7][C:6]=2[CH:17]=[C:2]([F:1])[C:3]=1[O:18][CH3:19]参加物
3
実験手順
4-(5-Fluoro-6-methoxybenzothiazol-2-yl)-5-methyl-2H-pyrazol-3-ylamine (596 mg; 2.14 mmol) was mixed with 4 mL of sulfuryl chloride. The reaction was stirred at room temperature for several hours and then the reaction was quenched by the addition of water. The resulting precipitate was isolated by filtration to yield 417 mg (62%) of the title compound. MS (m/z, ES+): 364.2 (M+1, 100%).
後処理
- customthe reaction was quenched by the addition of water
- customThe resulting precipitate was isolated by filtration