7-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine → (4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

HRID 19604ノート

反応式

HRID 19604 の反応式
CS([C:5]1[N:10]2[N:11]=[CH:12][CH:13]=[C:9]2[CH:8]=[C:7]([C:14]2[CH:15]=[C:16]([C:20]3[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=3)[CH:17]=[CH:18][CH:19]=2)[N:6]=1)(=O)=O.[C:28]([O:32][C:33](=[O:52])[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42](=[O:51])[NH:43][C:44]2[CH:49]=[CH:48][C:47]([NH2:50])=[CH:46][CH:45]=2)=[CH:38][CH:37]=1)([CH3:31])([CH3:30])[CH3:29]>>[C:28]([O:32][C:33](=[O:52])[NH:34][CH2:35][C:36]1[CH:41]=[CH:40][C:39]([C:42](=[O:51])[NH:43][C:44]2[CH:45]=[CH:46][C:47]([NH:50][C:5]3[N:10]4[N:11]=[CH:12][CH:13]=[C:9]4[CH:8]=[C:7]([C:14]4[CH:15]=[C:16]([C:20]5[CH:25]=[CH:24][C:23]([O:26][CH3:27])=[CH:22][CH:21]=5)[CH:17]=[CH:18][CH:19]=4)[N:6]=3)=[CH:48][CH:49]=2)=[CH:38][CH:37]=1)([CH3:31])([CH3:29])[CH3:30]

参加物

3

反応物 2

HCID 673176537-Methanesulfonyl-5-(4'-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidineHCID 67319189[4-(4-Amino-phenylcarbamoyl)-benzyl]-carbamic acid tert-butyl ester2 回

生成物 1

HCID 67319203(4-{4-[5-(4'-Methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidin-7-ylamino]-phenylcarbamoyl}-benzyl)-carbamic acid tert-butyl ester

反応条件

温度
130 °C

実験手順

Under an inert gas atmosphere at 130° C. bath temperature is heated neat a mixture of 7-methanesulfonyl-5-(4′-methoxy-biphenyl-3-yl)-pyrazolo[1,5-c]pyrimidine and [4-(4-amino-phenylcarbamoyl)-benzyl]-carbamic acid tertbutyl ester (compound B3) overnight. The crude product is purified by silica gel flash chromatography.

後処理

  1. customThe crude product is purified by silica gel flash chromatography

出典と根拠

ORDレコード
ord-4b05f3aff05e4cd38be34cf9b4a03da6
出典データセット
uspto-grants-2010_06
特許番号
US07745446B2

反応ノート

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