5-(4-Iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine → 3-Bromo-5-(4-iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidine
反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:13]=[C:12]([S:14][CH3:15])[N:11]3[N:16]=[CH:17][CH:18]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1.[Br:19]N1C(=O)CCC1=O.ClC1C=CC=CC=1>>[Br:19][C:18]1[CH:17]=[N:16][N:11]2[C:10]=1[CH:9]=[C:8]([C:5]1[CH:6]=[CH:7][C:2]([I:1])=[CH:3][CH:4]=1)[N:13]=[C:12]2[S:14][CH3:15]参加物
3
実験手順
To a solution of 5-(4-iodo-phenyl)-7-methylsulfanyl-pyrazolo[1,5-c]pyrimidin (1000 mg) in chlorobenzene N-bromosuccinimide (730 mg) is added. The mixture is stirred for 1 hour then the chlorobenzene is evaporated. The residue is partitioned between ethylacetate and sodium-hydrogencarbonate (5%).
後処理
- customthe chlorobenzene is evaporated
- customThe residue is partitioned between ethylacetate and sodium-hydrogencarbonate (5%)
出典と根拠
- ORDレコード
- ord-3db5d3632b8b4049bcffda686f654c4d
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745446B2
反応ノート
読み込み中…