Thiosemicarbazide → HCID 178527901、化合物
反応式
[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=O)[CH2:9][C:10](=O)[CH:11]=[CH:12]OC)=[CH:4][CH:3]=1.[NH2:17][NH:18][C:19]([NH2:21])=[S:20]>CO>[I:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:21][C:19](=[S:20])[N:18]3[N:17]=[CH:12][CH:11]=[C:10]3[CH:9]=2)=[CH:4][CH:3]=1参加物
4
実験手順
A mixture of 1-(4-iodo-phenyl)-5-methoxy-pent-4-ene-1,3-dione (compound F1)(1.9 g) and thiosemicarbazide (5 g) in methanol (220 ml) is heated to reflux temperature. After the reaction is completed the solid is filtered and washed with methanol. The filtrate with the product is purified by flash silica gel chromatography.
後処理
- temperatureis heated
- temperatureto reflux temperature
- filtrationis filtered
- washwashed with methanol
- customThe filtrate with the product is purified by flash silica gel chromatography
出典と根拠
- ORDレコード
- ord-1a283ebeecc94dc18563be03e16f73f1
- 出典データセット
- uspto-grants-2010_06
- 特許番号
- US07745446B2
反応ノート
読み込み中…