Ether hydrochloride → (4-Azido-3-iodophenyl)methanamine hydrochloride

反応式

[N:1]([C:4]1[CH:18]=[CH:17][C:7]([CH2:8][NH:9]C(=O)OC(C)(C)C)=[CH:6][C:5]=1[I:19])=[N+:2]=[N-:3].O(CC)CC.[ClH:25]>>[ClH:25].[N:1]([C:4]1[CH:18]=[CH:17][C:7]([CH2:8][NH2:9])=[CH:6][C:5]=1[I:19])=[N+:2]=[N-:3]

参加物

反応物 2

HCID 10953452Ether hydrochloride

HCID 86661980tert-Butyl 4-azido-3-iodobenzylcarbamate

生成物 1

HCID 86661981(4-Azido-3-iodophenyl)methanamine hydrochloride収率 45%

実験手順

tert-Butyl 4-azido-3-iodobenzylcarbamate (936.0 mg, 2.5 mmol) was dissolved in Et2O.HCl (2.0 N in Et2O) (10 ml) was added to the solution. The mixture was stirred at r.t. overnight. The solvent was removed under vacuum and the residue washed with a mixture of CH2Cl2 and MeOH (8:2) affording 350 mg (45%) of the title compound.

後処理

additionwas added to the solution
customThe solvent was removed under vacuum
washthe residue washed with a mixture of CH2Cl2 and MeOH (8:2)

出典と根拠

ORDレコード: ord-373f551e086a4231bdfd939c8284ff61
出典データセット: uspto-grants-2013_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08415333B2

反応ノート

読み込み中…

参加物