Acetyl chloride → HCID 178471808、化合物

HRID 1961655ノート

反応式

HRID 1961655 の反応式
Cl.[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:12][CH2:11][C@H:10]([NH2:13])[CH2:9][CH2:8]1)[CH3:3].CCN(CC)CC.[C:22](Cl)([CH3:24])=[O:23]>C(Cl)Cl>[CH2:2]([O:4][C:5](=[O:14])[CH2:6][C@H:7]1[CH2:8][CH2:9][C@H:10]([NH:13][C:22](=[O:23])[CH3:24])[CH2:11][CH2:12]1)[CH3:3]

参加物

5

反応物 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 178471807HCID 178471807、化合物2 回

生成物 1

HCID 178471808HCID 178471808、化合物収率 82.2%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

(trans-4-Amino-cyclohexyl)-acetic acid ethyl ester hydrochloride (10.0 g, 45 mmol, intermediate B) was dissolved in CH2Cl2 (150 ml) and Et3N and AcCl (3.89 g, 50 mmol) were added. The reaction mixture was stirred 3 h at room temperature before washing it with H2O and brine. After drying (Na2SO4) the solvent was evaporated to yield 8.42 g (82%, 37 mmol) of a white solid. MS (m/z): 228.3 ([M+H]+).

後処理

  1. washbefore washing it with H2O and brine
  2. dry with materialAfter drying (Na2SO4) the solvent
  3. customwas evaporated

出典と根拠

ORDレコード
ord-3f4fe37a8cd743969f0adc1b37292c10
出典データセット
uspto-grants-2013_04
特許番号
US08415350B2

反応ノート

読み込み中…