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2-Methyl-2-pentene → 5-bromo-2,3-dihydro-1H-indene-1-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Methyl-2-pentene | HCID 12243 | — |
| 反応物 | Sodium Chlorite | HCID 23668197 | — |
| 反応物 | Monosodium phosphate | HCID 23672064 | — |
| 反応物 | (E)-5-bromo-1-(methoxymethylene)-2,3-dihydro-1H-indene | HCID 58909702 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | tert-Butanol | HCID 6386 | — |
| 生成物 | 5-bromo-2,3-dihydro-1H-indene-1-carboxylic acid | HCID 13840006 | 56% |
反応手順
To a solution of the product from Example 100, Part B (300 mg, 1.3 mmol) and 2-methyl-2-pentene (8 ml) in tert-butanol (32 ml) was added a solution of sodium chlorite (1.36 g, 0.12 mmol) in H2O (12 ml) containing sodium dihydrogen phosphate (1.07 g, 8.9 mmol) and the mixture was stirred vigorously for 20 min at room temperature. Solvents were concentrated in vacuo and the residue was diluted with H2O, extracted with EtOAc (3×), extracts combined, dried (Na2SO4), and concentrated in vacuo to give the title compound (180 mg, 56%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415351B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-4a587beca0ca49bd8cddf20c7ccf0692 |
| 出典メモ | uspto-grants-2013_04 |