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Pyrrolidine → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| 反応物 | 4-Bromo-5-isoquinolinesulfonyl chloride | HCID 14580058 | — |
| 反応物 | 4-Chloroisoquinoline-5-sulfonyl chloride | HCID 22121908 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | (R)-1-(4-chloro-5-isoquinolinesulfonyl)-3-(methylamino)pyrrolidine | HCID 67243985 | — |
| 生成物 | (R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 67245481 | — |
反応手順
(R)-3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(4-chloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 21b) was prepared by using 4-chloro-5-isoquinolinesulfonyl chloride and (R)-31N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine in the method of Example 1-3, Step A instead of 4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 1-3, Step B in a similar manner to obtain the title compound as hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415372B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-ab1d6ed75d934fd3a1ba91497507b921 |
| 出典メモ | uspto-grants-2013_04 |