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3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine → Hydrochloric Acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(N-tert-Butoxycarbonyl-N-methylamino)pyrrolidine | HCID 2761404 | — |
| 反応物 | (S)-Methyl-pyrrolidin-3-yl-carbamic acid tert-butyl ester | HCID 7171888 | — |
| 反応物 | 5-Isoquinolinesulfonyl chloride,1,4-dichloro- | HCID 76851489 | — |
| 反応物 | 5-Isoquinolinesulfonyl chloride,4-bromo-1-chloro- | HCID 76851490 | — |
| 反応物 | 3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine | HCID 86627812 | — |
| 生成物 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | HCID 178482264 | HCID 178482264 | — |
反応手順
3-[N-(tert-Butoxycarbonyl)-N-methylamino]-1-(1,4-dichloro-5-isoquinolinesulfonyl)pyrrolidine (Intermediate 25) can be prepared by using 1,4-dichloro-5-isoquinolinesulfonyl chloride and 3-[N-(tert-butoxycarbonyl)-N-methyl-amino]pyrrolidine in the method of Example 35-1, Step A instead of 1-chloro-4-bromo-5-isoquinolinesulfonyl chloride and (S)-3-[N-(tert-butoxycarbonyl)-N-methylamino]pyrrolidine, respectively, and then used in the method of Example 35-1, Step B in a similar manner to obtain the title compound as hydrochloride.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08415372B2 |
| 出典データセット | uspto-grants-2013_04 |
| ORD ID | ord-09978fa3d05b45c5ad10dd94eccb3dfc |
| 出典メモ | uspto-grants-2013_04 |