Hydrochloride methanol → Hydrochloric Acid

反応式

C(OC([NH:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:16])=[O:15])[CH2:10]1)=O)(C)(C)C.[ClH:29].CO>>[NH2:8][C@H:9]1[CH2:13][CH2:12][N:11]([S:14]([C:17]2[C:18]3[C:19]([Cl:28])=[CH:20][N:21]=[C:22]([NH2:27])[C:23]=3[CH:24]=[CH:25][CH:26]=2)(=[O:15])=[O:16])[CH2:10]1.[ClH:29]

参加物

反応物 2

HCID 21893726Hydrochloride methanol

HCID 67243408(S)-3-(tert-Butoxycarbonyl)amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

生成物 2

HCID 313Hydrochloric Acid

HCID 67242685(S)-3-Amino-1-(1-amino-4-chloro-5-isoquinolinesulfonyl)pyrrolidine

実験手順

Intermediate 28s (30 mg) obtained in Step A mentioned above was added with 10% hydrogen chloride/methanol (4 ml), and the mixture was stirred at room temperature for 20 hours. The solvent was evaporated under reduced pressure to obtain the title compound as hydrochloride (25 mg).