2-Dimethylaminopyridine → 2-(3-Ethynyl-quinolin-6-yloxy)-2-methoxy-n-(2-methoxy-1,1-dimethyl-ethyl)-acetamide

HRID 1962859ノート

反応式

HRID 1962859 の反応式
[C:1]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([O:13][CH:14]([O:18][CH3:19])[C:15]([OH:17])=O)=[CH:8][CH:7]=2)#[CH:2].Cl.[CH3:21][O:22][CH2:23][C:24]([NH2:27])([CH3:26])[CH3:25].CN(C1C=CC=CN=1)C.F[P-](F)(F)(F)(F)F.N1(O[P+](N(C)C)(N(C)C)N(C)C)C2C=CC=CC=2N=N1>CN(C)C=O.[Cl-].[Na+].O>[C:1]([C:3]1[CH:4]=[N:5][C:6]2[C:11]([CH:12]=1)=[CH:10][C:9]([O:13][CH:14]([O:18][CH3:19])[C:15]([NH:27][C:24]([CH3:26])([CH3:25])[CH2:23][O:22][CH3:21])=[O:17])=[CH:8][CH:7]=2)#[CH:2]

参加物

7

反応物 4

HCID 218852-DimethylaminopyridineHCID 151348Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphateHCID 212557121-Methoxy-2-methylpropan-2-amine hydrochlorideHCID 59565329(3-Ethynyl-quinolin-6-yloxy)-metoxy-acetic acid

生成物 1

HCID 595653012-(3-Ethynyl-quinolin-6-yloxy)-2-methoxy-n-(2-methoxy-1,1-dimethyl-ethyl)-acetamide収率 86.6%

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 57417360Sodium chloride; water溶媒

実験手順

To a solution of (3-ethynyl-quinolin-6-yloxy)-metoxy-acetic acid (150 mg) in dry dimethylformamide (7 mL) were added 2-metoxy-1,1-dimethyl-ethylamine hydrochloride (81 mg) N-ethyldiisopropylamine (0.25 mL), dimethylaminopyridine (catalytic quantity) and (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (297 mg). The reaction mixture was stirred at room temperature for 18 hours. The mixture was poured over brine and extracted twice with ethyl acetate (thrice). The organic layer was washed with water then with brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude was purified by chromatography eluting with cyclohexane/ethyl acetate (7:3 by volume), to give 2-(3-ethynyl-quinolin-6-yloxy)-2-methoxy-N-(2-methoxy-1,1-dimethyl-ethyl)-acetamide (172 mg) as an oil.

後処理

  1. extractionextracted twice with ethyl acetate (thrice)
  2. washThe organic layer was washed with water
  3. dry with materialwith brine, dried over sodium sulphate
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure
  6. customThe crude was purified by chromatography
  7. washeluting with cyclohexane/ethyl acetate (7:3 by volume)

出典と根拠

ORDレコード
ord-aac07bc2f04b40839bc13df906ed2bfb
出典データセット
uspto-grants-2013_04
特許番号
US08415272B2

反応ノート

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