Hydrochloric Acid → 2-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol

HRID 1962875

反応式

HRID 1962875 の反応式
[CH3:1][C:2]1([CH2:12][O:13]CC#C)[NH:6][C:5]2(CCC[CH2:8][CH2:7]2)[O:4][CH2:3]1.Cl>O>[NH2:6][C:2]([CH3:1])([CH2:3][O:4][CH2:5][C:7]#[CH:8])[CH2:12][OH:13]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 595654083-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane

生成物 1

HCID 595653842-Amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol収率 102.7%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

3-Methyl-3-prop-2-ynyloxymethyl-1-oxa-4-aza-spiro[4.5]decane (1.83 g) in an aqueous solution of HCl (6N) (2.73 ml) were refluxed for 1 hr. The reaction mixture was cooled down to room temperature, diluted with water and extracted thrice with ethyl ether. The two layers were separated. The aqueous layer was concentrated under reduced pressure to yield 2-amino-2-methyl-3-prop-2-ynyloxy-propan-1-ol hydrochloric salt (1.205 g) as a white beige solid which was used as such in Stage 3 described below. 1H NMR (DMSO) δ ppm: 8.02 (3H, s br); 5.47 (1H, s br); 4.21 (2H, s); 3.54-3.49 (5H, m); 1.15 (3H, s).

後処理

  1. extractionextracted thrice with ethyl ether
  2. customThe two layers were separated
  3. concentrationThe aqueous layer was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-ae3bb24121ea4854a6d21cbb4a62e16d
出典データセット
uspto-grants-2013_04
特許番号
US08415272B2

関連ノート

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