Phosphorus oxychloride → 2-Chloro-4-methyl-6-(6-trifluoromethyl-pyridin-3-yl)-pyrimidine
反応式
[CH3:1][C:2]1[NH:7][C:6](=O)[N:5]=[C:4]([C:9]2[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)[CH:3]=1.O=P(Cl)(Cl)[Cl:21]>>[Cl:21][C:6]1[N:7]=[C:2]([CH3:1])[CH:3]=[C:4]([C:9]2[CH:10]=[N:11][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:13][CH:14]=2)[N:5]=1参加物
3
実験手順
The title compound was prepared from 6-methyl-4-(6-trifluoromethyl-pyridin-3-yl)-1H-pyrimidin-2-one (2.0 g, 7.84 mmol) and phosphoroxychloride (12 ml) according to the general procedure I. Obtained as an orange solid (1.33 g, 62%). MS (ISP) 274.1 [(M+H)+]; mp 123.5° C.
出典と根拠
- ORDレコード
- ord-80fd46f16ad642d6bca52eb6db896956
- 出典データセット
- uspto-grants-2013_04
- 特許番号
- US08415380B2
反応ノート
読み込み中…