1-methyl-1H-pyrazol-4-amine dihydrochloride → 5-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide

HRID 1962970

反応式

HRID 1962970 の反応式
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[CH:17][C:18]([C:21]([OH:23])=O)=[N:19][CH:20]=1.Cl.Cl.[CH3:26][N:27]1[CH:31]=[C:30]([NH2:32])[CH:29]=[N:28]1>>[CH3:26][N:27]1[CH:31]=[C:30]([NH:32][C:21]([C:18]2[CH:17]=[CH:16][C:15]([O:14][CH2:13][C:3]3[C:4]([C:7]4[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=4)=[N:5][O:6][C:2]=3[CH3:1])=[CH:20][N:19]=2)=[O:23])[CH:29]=[N:28]1

参加物

3

反応物 2

HCID 448907531-methyl-1H-pyrazol-4-amine dihydrochlorideHCID 66644648HCID 66644648、化合物

生成物 1

HCID 498035865-(5-Methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (1-methyl-1H-pyrazol-4-yl)-amide収率 90%

実験手順

As described for example 7, 5-(5-methyl-3-pyridin-2-yl-isoxazol-4-ylmethoxy)-pyridine-2-carboxylic acid (100 mg, 0.32 mmol) was converted, using 1-methyl-1H-pyrazol-4-ylamine dihydrochloride instead of isopropylamine, to the title compound (113 mg, 90%), which was obtained as a white solid. MS: m/e=391.1 [M+H]+.

出典と根拠

ORDレコード
ord-47997a2828bc4877b03341a893072928
出典データセット
uspto-grants-2013_04
特許番号
US08415379B2

関連ノート

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