2-(Phenylmethyl)pyridine → 2-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine

HRID 1963043ノート

反応式

HRID 1963043 の反応式
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[C:6]=1[CH3:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[F:11][C:7]1[C:6]([CH3:12])=[C:5]([CH:10]=[CH:9][CH:8]=1)[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

参加物

4

反応物 2

HCID 75812-(Phenylmethyl)pyridineHCID 866706671-Bromo-3-(3-fluoro-2-methyl-phenyl)-propan-2-one

生成物 1

HCID 677730242-(3-Fluoro-2-methyl-benzyl)-1-phenyl-indolizine収率 33.8%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The compound of step 2 (1.50 g, 6.12 mmol) and 2-benzyl-pyridine (2.071 g, 12.24 mmol) were dissolved in acetone (30 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (cyclohexane) to give 0.653 g of the title compound.

後処理

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (cyclohexane)

出典と根拠

ORDレコード
ord-a857ff382b0a4e8abaa8d4ebf918fd2d
出典データセット
uspto-grants-2013_04
特許番号
US08415336B2

反応ノート

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