2-(Phenylmethyl)pyridine → HCID 67772676、化合物

HRID 1963049ノート

反応式

HRID 1963049 の反応式
Br[CH2:2][C:3](=O)[CH2:4][C:5]1[C:10]([F:11])=[CH:9][CH:8]=[CH:7][C:6]=1[Cl:12].[CH2:14]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1>CC(C)=O>[Cl:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([F:11])[C:5]=1[CH2:4][C:3]1[C:14]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:21]2[N:22]([CH:2]=1)[CH:23]=[CH:24][CH:25]=[CH:26]2

参加物

4

反応物 2

HCID 75812-(Phenylmethyl)pyridineHCID 80147526HCID 80147526、化合物

生成物 1

HCID 67772676HCID 67772676、化合物収率 76.3%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

The compound of step 1 (1.17 g, 4.41 mmol) and 2-benzyl-pyridine (1.49 g, 8.82 mmol) were dissolved in acetone (15 ml) and the mixture was stirred under reflux overnight. The mixture was concentrated to dryness and the residue was purified by chromatography on silica gel (DCM/MOH, 100:0, then 95:5) to give 1.13 g of the title compound.

後処理

  1. temperatureunder reflux overnight
  2. concentrationThe mixture was concentrated to dryness
  3. customthe residue was purified by chromatography on silica gel (DCM/MOH, 100:0

出典と根拠

ORDレコード
ord-f019980b3a7a4707b5c4643159388c93
出典データセット
uspto-grants-2013_04
特許番号
US08415336B2

反応ノート

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